Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Recommanded Product: 5′-O-[Bis(4-Methoxyphenyl)phenylmethyl]-thymidine 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite], 98796-51-1, Name is 5′-O-[Bis(4-Methoxyphenyl)phenylmethyl]-thymidine 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite], molecular formula is C40H49N4O8P, belongs to naphthyridines compound. In a document, author is Hou, Xueyan, introduce the new discover.
Synthesis and biological evaluation of 3-(1,3,4-oxadiazol-2-yl)-1,8-naphthyridin-4(1H)-ones as cisplatin sensitizers
A series of novel 3-(1,3,4-oxadiazol-2-yl)-1,8-naphthyridin-4(1H)-one derivatives were synthesized and their anti-cancer as well as cisplatin sensitization activities were evaluated. Among them, compounds 6e and 6h exhibited significant cisplatin sensitization activity against HCT116. Hoechst staining and annexin V-FITC/PI dual-labeling studies demonstrated that the combination of 6e/6h and cisplatin can induce tumour cell apoptosis. Western blot showed that the expression of ATR downstream protein, CHK1, decreased in 6e + cisplatin and 6h + cisplatin groups compared with that in the test compound and cisplatin group. Furthermore, docking of 6e/6h into the ATR structure active site revealed that the N1 and N8 atoms in the naphthyridine ring and the hybrid atom in the oxadiazole ring are involved in hydrogen bonding with Val170, Glu168 and Tyr155. Additionally, the naphthyridine ring is also involved in – stacking with Trp169. Accordingly, compounds 6e and 6h can be expected to be potential cisplatin sensitizers that can participate in HCT116 cancer therapy.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 98796-51-1. Recommanded Product: 5′-O-[Bis(4-Methoxyphenyl)phenylmethyl]-thymidine 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite].
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem