Reference of 23814-12-2, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 23814-12-2, Name is 1H-Benzo[d][1,2,3]triazole-5-carboxylic acid, SMILES is O=C(C1=CC=C(NN=N2)C2=C1)O, belongs to naphthyridines compound. In a article, author is Makhanya, Talent Raymond, introduce new discover of the category.
Phosphotungstic Acid Catalyzed One Pot Synthesis of 4,8,8-Trimethyl-5-phenyl-5,5a,8,9-tetrahydrobenzo[b] [1,8]Naphthyridin-6(7H)-one Derivatives and Their Biological Evaluation Against A549 Lung Cancer Cells
A facile one pot multicomponent synthesis of 1,8-naphthyridinone derivatives was developed using a mild and reusable phosphotungstic acid catalyst. A 2-amino picoline, benzaldehyde derivatives and 1,3-dicarbonyl cyclohexane were used to synthesize 1,8-naphthyridinones, which was achieved by conventional heating under solvent-free conditions. All synthesized compounds were characterized by spectral analysis and screened for anticancer activity against A549 lung cancer cells. The results from the cell viability assay showed that the synthesized compounds do have a biological effect at various concentrations on the lung cancer cells. Compounds 4F-p-CF3 and 4H-VAN showed potential as an antiproliferative agent and a dose-dependent decline in cell viability was observed.
Reference of 23814-12-2, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 23814-12-2.
Reference:
1,8-Naphthyridine – Wikipedia,
,1,8-Naphthyridine | C8H6N2 – PubChem