7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid, cas is 100361-18-0, it is a common heterocyclic compound, the naphthyridine compound, its synthesis route is as follows.
Acetonitrile (100ml), 3-aminomethyl-4-methoxyiminopyrrolydine dimethanesulfonate (12. 5g) and 1-naphthaldehyde (11. lg) were in turn introduced into a reaction vessel at room temperature and cooled to 0~5 C. Triethylamine (12.2g) was dropwise added to the reaction mixture. After stirring the mixture for about 0. 5h, the reaction mixture was diluted by adding ethanol (30ml). 7-Chloro-l-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxo- 1, 8-naphthyridine-3-carboxylic acid (lO. Og) was introduced to the reaction mixture. After raising slowly the reaction temperature to room temperature, the reaction mixture was stirred for about 15h. The title compound in the form of solid was filtered, washed with water and ethanol, and dried to prepare 15.7 g of the title compound (Yield: 84. 4%). 1H NMR (o, CDCl3) : 8.86 (m, 2H), 8.55 (s, 1H), 7. 82 (m, 3H), 7.73 (m, 1H), 7.40 (m, 3H), 4.60 (m, 2H), 4.24 (m, 2H), 4.08 (m, 1H), 3.99 (m, 1H), 3.95 (s, 3H), 3.45 (m, 2H), 1.13 (m, 2H), 0. 89 (m, 2H) Mass (FAB): 528 (M+H)
100361-18-0, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,100361-18-0 ,7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid, other downstream synthetic routes, hurry up and to see
Reference£º
Patent; LG LIFE SCIENCES LTD.; WO2003/87100; (2003); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem