Reference of 5174-90-3, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 5174-90-3, Name is Ethyl 2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate,introducing its new discovery.
The CB2 receptor activation can be exploited for the treatment of diseases such as chronic pain and tumors of immune origin, devoid of psychotropic activity. On the basis of our already reported 1,8-naphthyridin- 4(1H)-on-3-carboxamide derivatives, new 1,8-naphthyridin-2(1H)-on-3-carboxamide derivatives were designed, synthesized, and tested for their affinities toward the human CB1 and CB2 cannabinoid receptors. Some of the reported compounds showed a subnanomolar CB2 affinity with a CB 1/CB2 selectivity ratio greater than 200 (compounds 6, 12, cis-12, 13, and cis-13). Further studies revealed that compound 12, which presented benzyl and carboxy-4-methylcyclohexylamide substituents bound in the 1 and 3 positions, exerted a CB2-mediated inhibitory action on immunological human basophil activation. On the human T cell leukemia line Jurkat the same derivative induced a concentration-dependent decrease of cell viability. The obtained results suggest that 1,8-naphthyridin-2(1H)-on-3- carboxamides represent a new scaffold very suitable for the development of new promising CB2 agonists.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 5174-90-3, and how the biochemistry of the body works.Reference of 5174-90-3
Reference£º
1,620-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N614 – PubChem