100361-18-0, Name is 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid, belongs to naphthyridine compound, is a common compound. SDS of cas: 100361-18-0In an article, once mentioned the new application about 100361-18-0.
A series of novel (R)/(S)-7-(3-alkoxyimino-2-aminomethyl-1-azetidinyl)fluoroquinolone derivatives were synthesized and evaluated for their invitro antibacterial activity against representative strains. Our results reveal that 12 of the target compounds generally show better activity (MIC: <0.008-0.5mugmL-1) against the tested Gram-positive strains including MRSA and MRSE than levofloxacin (LVFX, MIC: 0.125-8mugmL-1). Their activity is similar to that of gemifloxacin (GMFX, MIC: <0.008-4mugmL-1). However, they are generally less active than the two reference drugs against Gram-negative strains. Moreover, against clinical strains of S.aureus including MRSA and S.epidermidis including MRSE, the MIC50 values (0.06-16mugmL-1) and MIC90 values (0.5-32mugmL-1) of compounds 16w, y, and z are 2-8- and 2-16-fold less than LVFX, respectively, and 16w (MIC90 range: 0.5-4mugmL-1) was also found to be more active than GMFX (MIC90 range: 1-8mugmL-1).
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Reference£º
1,735-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N729 – PubChem