In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Formula: C8H5ClN2, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 7689-62-5, name is 2-Chloro-1,5-naphthyridine. In an article£¬Which mentioned a new discovery about 7689-62-5
The phosphoinositide 3-kinase (PI3K) family catalyzes the ATP-dependent phosphorylation of the 3?-hydroxyl group of phosphatidylinositols and plays an important role in cell growth and survival. There is abundant evidence demonstrating that PI3K signaling is dysregulated in many human cancers, suggesting that therapeutics targeting the PI3K pathway may have utility for the treatment of cancer. Our efforts to identify potent, efficacious, and orally available PI3K/mammalian target of rapamycin (mTOR) dual inhibitors resulted in the discovery of a series of substituted quinolines and quinoxalines derivatives. In this report, we describe the structure-activity relationships, selectivity, and pharmacokinetic data of this series and illustrate the in vivo pharmacodynamic and efficacy data for a representative compound.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 7689-62-5, help many people in the next few years.Formula: C8H5ClN2
Reference£º
1,470-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N464 – PubChem