Related Products of 254-60-4, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 254-60-4, Name is 1,8-Diazanaphthalene,introducing its new discovery.
A series of tacrine-based pyrazolo[4?,3?:5,6]pyrano[2,3-b]quinolines and related compounds were designed and synthesized for targeting AChE, BuChE and 15-LOX enzymes in the field of Alzheimer’s disease therapy. Most of compounds showed potent activity against cholinesterases and mild potency toward 15-LOX enzyme. In particular, compounds 29, 32 and 40 displayed inhibition at nano-molar level against AChE and BuChE (IC50s?=?0.005?0.08?muM), being more potent than reference drug tacrine. Moreover, compound 32 with IC50value of 31?muM was the most potent compound against 15-LOX. The cytotoxicity assay on HepG2 cells revealed that compounds 29 and 32 showed no significant cytotoxic activity even at concentration of 50?muM. The cytotoxicity of compounds 29 and 32 was significantly less than that of tacrine at higher concentrations.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 254-60-4, and how the biochemistry of the body works.Related Products of 254-60-4
Reference£º
1,227-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N221 – PubChem