Reference of 254-60-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.254-60-4, Name is 1,8-Diazanaphthalene, molecular formula is C8H6N2. In a Article£¬once mentioned of 254-60-4
In this paper we investigate the possibility of further increase the role of the N-donor aromatic base in antitumor Hollis-type compounds by conferring the possibility to act as a hydrogen-bond donor/acceptor. Therefore, we synthesized the PtII complex cis-[PtCl(NH3) 2(naph)]NO3 (1) containing the 1,8-naphthyridine (naph) ligand. The naphthyridine ligand is generally monodentate, and the second nitrogen atom can act as H-bond donor/acceptor depending upon its protonation state. The possibility of forming such an H-bond could be crucial in the interaction of the drug with DNA or proteins. Apart from the synthesis of the compound, in this study we evaluated its in vitro antitumor activity in a wide panel of tumor cell lines, also including cells selected for their sensitivity/resistance to oxaliplatin, which was compared with that of previously reported complex 2 ([PtI(2,9-dimethyl-1,10-phenanthroline)(1-methyl- cytosine)]I) and oxaliplatin and cisplatin as reference compounds. The cytotoxicity data were correlated with the cellular uptake and the DNA platination levels. Finally, the reactivity of 1 towards guanosine 5?-monophosphate (5′-GMP) and glutathione was investigated to provide insights into its mechanism of action. Monofunctional! The cationic monofunctional PtII complex cis-[PtCl(NH3) 2(naph)]+, containing the H-bond donor/acceptor ligand 1,8-naphthyridine, has been synthesized, characterized, and tested in vitro. The reactivity of the new compound towards GSH and 5?-GMP (as DNA model) was also investigated by multinuclear NMR spectroscopy.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 254-60-4, and how the biochemistry of the body works.Reference of 254-60-4
Reference£º
1,191-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N185 – PubChem