Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. COA of Formula: C14H12ClFN2O3. Introducing a new discovery about 96568-07-9, Name is Ethyl 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
We report herein the design and synthesis of novel 7-(3-alkoxyimino-5- amino/methylaminopiperidin-1-yl)fluoroquinolone derivatives based on the structures of new fluoroquinolones IMB and DZH. The antibacterial activity of these newly synthesized compounds was also evaluated and compared with gemifloxacin, ciprofloxacin, and levofloxacin. Results revealed that all of the target compounds 10-27 have good potency in inhibiting the growth of Staphylococcus aureus including MSSA (MIC: 0.125-8 mug/mL), Staphylococcus epidermidis including MRSE (MIC: 0.25-16 mug/mL), Streptococcus pneumoniae (MIC: 0.125-4 mug/mL), and Escherichia coli (MIC: 0.25-0.5 mug/mL). In particular, some compounds showed useful activity against several fluoroquinolone-resistant strains, and the most active compound 15 was found to be 16-128, 2-32, and 4-8-fold more potent than the three reference drugs against fluoroquinolone-resistant MSSA, MRSA, and MRSE.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.COA of Formula: C14H12ClFN2O3, you can also check out more blogs about96568-07-9
Reference£º
1,768-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N762 – PubChem