In heterogeneous catalysis, the catalyst is in a different phase from the reactants. name: 2-Methyl[1,8]-Naphthyridine, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 1569-16-0, name is 2-Methyl[1,8]-Naphthyridine. In an article£¬Which mentioned a new discovery about 1569-16-0
A Cu(i)-catalyzed retro-aldol reaction of beta-hydroxyketones with ortho-aminobenzaldehydes and nicotinaldehydes is reported that produces a range of quinolines and naphthyridines with high efficiency and selectivity. This reaction uses beta-hydroxyketones as a regiospecific ketone-protected enolate source via copper-catalyzed retro-aldol Calpha-Cbeta bond cleavage. The in situ generated copper enolate undergoes kinetically favorable cyclization with ortho-amino aryl aldehydes to produce quinolines and naphthyridines in a chemo- and regioselective manner. The mild and weakly basic reaction conditions also suppress possible side reactions of benzaldehydes under strongly basic conditions, resulting in improved reaction yields.
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Reference£º
1,377-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N371 – PubChem