One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, HPLC of Formula: C12H8ClFN2O3, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 100361-18-0, Name is 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid, molecular formula is C12H8ClFN2O3
A series of stereochemically pure 7-<3-(1-aminoethyl)-1-pyrrolidinyl>-1,4-dihydro-4-oxoquinoline and 1,8-naphthyridine-3-carboxylic acids, with varied substituents at the 1-, 5-, and 8-positions, were synthesized to study the effects of the 7-<3-(1-aminoethyl)-1-pyrrolidinyl> moiety on potency and in vivo efficacy relative to the known 7-<3-(aminomethyl)-1-pyrrolidinyl> derivatives. The antibacterial efficacies of the target compounds and their relevant reference agents were determined in vitro using an assortment of Gram-negative and Gram-positive organisms and in vivo using Escherichia coli and Streptococcus pyogenes mouse infection models. The effects of the 7-<3-(1-aminoethyl)-1-pyrrolidinyl> moiety were also examined at the level of the target enzyme by employing a DNA-gyrase supercoiling inhibition assay. Selected compounds were further evaluated for potential phototoxic and clastogenic liabilities using a phototoxicity mouse model and an in vitro mammalian cell cytotoxicity assay. It was found that the differences in in vitro antibacterial activity between the stereoisomers were significantly greater than previously reported for other optically pure 3-substituted pyrrolidinyl side chains. Relative to their 7-<3-(aminomethyl)-1-pyrrolidinyl> analogs, the (3R,1S)-3-(1-aminoethyl)pyrrolidines generally conferred a 2-4-fold increase in Gram-positive in vitro activity and an average of 10-fold improvement in oral efficacy. The level of phototoxicity and cytotoxicity of the product quinolones was ultimately determined by the combined influence of the 7-<3-(1-aminoethyl)-1-pyrrolidinyl> side chains and the other quinolone substituents. From this study, several compounds were identified with outstanding antibacterial activity and low degrees of phototoxicity and mammalian cell cytotoxicity. One such agent, 34F-R,S (PD 140248), showed the best overall blend of safety and efficacy.
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, HPLC of Formula: C12H8ClFN2O3, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 100361-18-0
Reference£º
1,716-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N710 – PubChem