In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Product Details of 952059-69-7, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 952059-69-7, name is 8-Chloro-3-methoxy-1,5-naphthyridine. In an article£¬Which mentioned a new discovery about 952059-69-7
Deregulation of the receptor tyrosine kinase c-Met has been implicated in several human cancers and is an attractive target for small molecule drug discovery. We previously showed that O-linked triazolopyridazines can be potent inhibitors of c-Met. Herein, we report the discovery of a related series of N-linked triazolopyridazines which demonstrate nanomolar inhibition of c-Met kinase activity and display improved pharmacodynamic profiles. Specifically, the potent time-dependent inhibition of cytochrome P450 associated with the O-linked triazolopyridazines has been eliminated within this novel series of inhibitors. N-linked triazolopyridazine 24 exhibited favorable pharmacokinetics and displayed potent inhibition of HGF-mediated c-Met phosphorylation in a mouse liver PD model. Once-daily oral administration of 24 for 22 days showed significant tumor growth inhibition in an NIH-3T3/TPR-Met xenograft mouse efficacy model.
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1,545-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N539 – PubChem