One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, SDS of cas: 100491-29-0, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 100491-29-0, Name is Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate, molecular formula is C17H10ClF3N2O3
A series of novel chiral 7-(1-, 3-, 4-, and 6-methyl<(1R,4R)-2,5-diazabicyclo<2.2.1.>heptan-2-yl>-substituted naphthyridines has been prepared with the aim of obtaining good in vitro and in vivo antibacterial agents with a decrease of the pseudoallergic type reaction when compared to that observed with 7-<(1R,4R)-2,5-diazabicyclo<2.2.1>heptan-2-yl)-1-(1,1-dimethylethyl)-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid (1a) (BMY 40062).The derivatives 7-(1R,4R,6S)-6-methyl-2,5-diazabicyclo<2.2.1.>heptan-2-yl>-1-(1,1-dimethylethyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid (41) and 7-<(1R,4R,6S)-6-methyl-2,5-diazabicyclo<2.2.1>heptan-2-yl>-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid (49) showed potent in vitro and in vivo antibacterial activity against Gram-positive and Gram-negative bacteria.The derivative 49 displayed a less marked decrease in blood pressure (MAP), compared to that of 1a, after intravenous infusion in dogs and was selected as a potential candidate for preclinical trials.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. SDS of cas: 100491-29-0, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 100491-29-0, in my other articles.
Reference£º
1,798-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N792 – PubChem