Electric Literature of 204452-90-4, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 204452-90-4, Name is 2-(Dimethoxymethyl)-1,8-naphthyridine, molecular formula is C11H12N2O2. In a Article£¬once mentioned of 204452-90-4
XJP-L (8), a derivative of the natural product (¡À)-7,8-dihydroxy-3-methylisochroman-4-one isolated from the peel of Musa sapien tum L., was found to exhibit weak inhibitory activity of tubulin polymerization (IC50 = 10.6 muM) in our previous studies. Thus, a series of 4-arylisochromene derivatives were prepared by incorporating the trimethoxyphenyl moiety into 8, among which compound (¡À)-19b was identified as the most potent compound with IC50 values ranging from 10 to 25 nM against a panel of cancer cell lines. Further mechanism studies demonstrated that (¡À)-19b disrupted the intracellular microtubule network, caused G2/M phase arrest, induced cell apoptosis, and depolarized mitochondria of K562 cells. Moreover, (¡À)-19b exhibited potent in vitro antivascular and in vivo antitumor activities. Notably, the R-configured enantiomer of (¡À)-19b, which was prepared by chiral separation, was slightly more potent than (¡À)-19b and was much more potent than the S-configured enantiomer in both antiproliferative and antitubulin assays. Our findings suggest that (¡À)-19b deserves further research as a potential antitubulin agent for the treatment of cancers.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 204452-90-4. In my other articles, you can also check out more blogs about 204452-90-4
Reference£º
1,573-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N567 – PubChem