In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 5174-90-3, name is Ethyl 2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate, introducing its new discovery. Formula: C11H10N2O3
Ethyl 1.8-naphthyridin-2-one-3-carboxylate 1 on fusion with different anilines at 200C affords N-aryl-1,8-naphthyridin-2-one-3-carboxamides 2, which undergo smooth cyclization with POCl3 yielding 1-arylazetidino [2,3-b][1,8]naphthyridin-2(1H)-ones 3. Compound 1 on treatment with POCl 3 yield ethyl 2-chloro-1,8-naphthyridine-3-carboxylate 4, which on reaction with aromatic acid hydrazides in methanol furnishes respective N-aroyl-N’-(3-carbethoxy-1,8-naphthyridin-2-yl) hydrazines 5. Cyclization of 5 with POCl3 under reflux result in the formation of 1-aryl-4-carbethoxy-1,2,4-triazol [4,3-a][1,8]naphthyridines 6. Compounds 3 and 6 have been evaluated for their antibacterial activity using streptomycin as a reference compound.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 5174-90-3, and how the biochemistry of the body works.Formula: C11H10N2O3
Reference£º
1,622-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N616 – PubChem