Electric Literature of 254-60-4, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 254-60-4, Name is 1,8-Diazanaphthalene,introducing its new discovery.
Background: Indole-naphthyridine derivatives are known to exhibit a wide range of anticancer activities, that has attracted the attention for drug design, synthesis, identification and development of potential anticancer agents from Indole-naphthyridine family as New Chemical Entities (NCEs). Methods: Ag-loaded PdTi3O7 nano particles are efficient catalysts for the activation of C-H bond and the formation of both intra molecular C-N bonds to form the fused heterocyclic system. The target molecules were established by choosing various types of functional groups on aryl acetonitiriles moiety with 2-aminonicotinaldehyde in conventional and microwave irradiation conditions. All the indole-naphthyridine derivatives were characterized by microanalyses, SEM,1H NMR,13C NMR and mass spectral techniques. Results: Interestingly, few target compounds possess significant invitro antitumor activities against human breast cancer cell line MCF-7, human normal cell line HEK293T. Among them, compounds 3c, 3a, 3g and 3e, 3a, 3f exhibited better inhibitory activities against MCF-7 and HEK293T cell respectively compared to other target molecules. Conclusion: Our study revealed that the molecular framework presented here could be a useful template for the identification of novel indole-naphthyridine molecules as promising anticancer agents.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 254-60-4, and how the biochemistry of the body works.Electric Literature of 254-60-4
Reference£º
1,269-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N263 – PubChem