100491-29-0, An article , which mentions 100491-29-0, molecular formula is C17H10ClF3N2O3. The compound – Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate played an important role in people’s production and life.
The bactericidal activities of monotherapy with trovafloxacin (-0.37 ¡À 0.15 Deltalog10 CFU/ml ¡¤ h), vancomycin (-0.32 ¡À 0.12 Deltalog10 CFU/ml ¡¤ h), and ceftriaxone (-0.36 ¡À 0.19 Deltalog10 CFU/ml ¡¤ h) for the treatment of experimental meningitis in rabbits due to a clinical penicillin-resistant pneumococcal strain (MIC, 4 mg/liter) were similar. The combination of ceftriaxone with trovafloxacin considerably improved the killing rates (-0.67 ¡À 0.16 Deltalog10 CFU/ml ¡¤ h) and was slightly superior to ceftriaxone with vancomycin (killing rate, -0.53 ¡À 0.22 Deltalog10 CFU/ml ¡¤ h), the regimen most commonly used in clinical practice. In vitro, synergy was demonstrated between ceftriaxone and trovafloxacin by the checkerboard method (fractional inhibitory concentration index, 0.5) and by time-killing assays over 8 h.
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Reference£º
1,795-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N789 – PubChem