100491-29-0, In an article, published in an article,authors is Bradley, John S., once mentioned the application of 100491-29-0, Name is Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate,molecular formula is C17H10ClF3N2O3, is a conventional compound. this article was the specific content is as follows.
The pharmacokinetics of trovafloxacin following administration of a single intravenous dose of alatrofloxacin, equivalent to 4 mg of trovafloxacin per kg of body weight, were determined in 6 infants (ages 3 to 12 months) and 14 children (ages, 2 to 12 years). There was rapid conversion of alatrofloxacin to trovafloxacia, with an average ¡À standard deviation (SD) peak trovafloxacin concentration determined at the end of the infusion of 4.3 ¡À 1.4 mug/ml. The primary pharmacokinetic parameters (average ¡À SD) analyzed were volume of distribution at steady state (1.6 ¡À 0.6 liters/kg), clearance (151 ¡À 82 ml/h/kg), and half-life (9.8 ¡À 2.9 h). The drug was well tolerated by all children. There were no age-related differences in any of the pharmacokinetic parameters studied. Less than 5% of the administered dose was excreted in the urine over 24 h. On the basis of the mean area under the concentration-time curve of 30.5 ¡À 10.1 mug ¡¤ h/ml and the susceptibility (?0.5 mug/ml) of common pediatric bacterial pathogens to trovafloxacin, dosing of 4 mg/kg/day once or twice daily should be appropriate.
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Reference£º
1,792-Naphthyridine – Wikipedia,
1,8-Naphthyridine | C8H6N786 – PubChem