As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO226,mainly used in chemical industry, its synthesis route is as follows.,23616-31-1
EXAMPLE 3 8Bromo-1,6-naphthyridine-5(6H) -one (5) A suspension of 1.462 g (10 mmol) of 1,6-naphthyridine-5(6H)-one (3), 1.96 g (11 mmol) of N-bromosuccinimide, and 30 mL of dry dichlorothane is stirred at 25¡ã C. for 3.5 hours. The mixture is filtered, the solids are washed successively with small amounts of chloroform, water, and ether, then dried to leave 2.0 g of white solid, mp 245¡ã-250¡ã C. This is combined with 348 mg from an earlier run. The solids are triturated in 15 mL of hot water, collected by filtration, and dried to leave 2.28 g of pure product, mp 247¡ã-251¡ã C. A suspension of 360 mg of the product in methanol is treated with an excess of 2-propanoic hydrogen chloride, heated for 3 to 5 minutes, and stored at 25¡ã C. for 1.5 hours. The solids are collected by filtration, washed with 2-propanol, and dried to give 410 mg of yellow powder as the hydrochloride salt, mp >245¡ã C. (decomposition).
With the complex challenges of chemical substances, we look forward to future research findings about 1,6-Naphthyridin-5(6H)-one,belong naphthyridine compound
Reference£º
Patent; Warner-Lambert Company; US5391554; (1995); A;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem