Analyzing the synthesis route of 3-Bromo-1,7-naphthyridin-8(7H)-one

With the synthetic route has been constantly updated, we look forward to future research findings about 3-Bromo-1,7-naphthyridin-8(7H)-one,belong naphthyridine compound

As a common heterocyclic compound, it belong naphthyridine compound,3-Bromo-1,7-naphthyridin-8(7H)-one,1375301-90-8,Molecular formula: C8H5BrN2O,mainly used in chemical industry, its synthesis route is as follows.,1375301-90-8

A mixture of compound E3 (2.0 g, 8.89 mmol), sodium methanolate (2.40 g, 44.4mmol) and copper(I) iodide (846 mg, 4.44 mmol) in DMF (20 mL) was stirred at 100 C for 16 hunder N2. Then mixture was concentrated to give cmde E4 which was used in the next stepwithout further purification.

With the synthetic route has been constantly updated, we look forward to future research findings about 3-Bromo-1,7-naphthyridin-8(7H)-one,belong naphthyridine compound

Reference£º
Patent; MERCK SHARP & DOHME CORP.; SCOTT, Jack, D.; BLIZZARD, Timothy, A.; WALSH, Shawn, P.; CUMMING, Jared, N.; (105 pag.)WO2017/95759; (2017); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem