15944-34-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7-Chloro-1,8-naphthyridin-2-ol, cas is 15944-34-0,the naphthyridine compound, it is a common compound, a new synthetic route is introduced below.
10. i. 7-methoxy-lH-[l, 8]naphthyridin-2-one:To a solution of 7-chloro-lH-[l,8]naphthyridin-2-one (prepared as described in J. Org. Chem. (1990), 55, 4744; 5.36 g, 29.68 mmol) in MeOH (98 niL) was added sodium methoxide (25 wt% in MeOH, 161 mL). The resulting solution was stirred at reflux for15 h. The solvent was removed in vacuo. Water (100 mL) and EA (80 mL) were added.The phases were separated and the aq layer was extracted with EA (8 x 80 mL). The combined org. layers were washed with brine (50 mL), dried over MgSO4, filtered and evaporated under reduced pressure. The title compound was obtained as a beige solid(5.22 g, 100% yield).1H NMR (d6DMSO) delta: 11.96 (s, 1eta); 7.96 (d, J = 8.5 Hz, IH); 7.81 (d, J = 9.4 Hz, IH); 6.63 (d, J = 8.5 Hz, IH); 6.34 (d, J = 9.4 Hz, IH); 3.90 (s, 3H).
The chemical industry reduces the impact on the environment during synthesis,15944-34-0,7-Chloro-1,8-naphthyridin-2-ol,I believe this compound will play a more active role in future production and life.
Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; WO2009/147616; (2009); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem