It is a common heterocyclic compound, the naphthyridine compound, 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid, cas is 100361-18-0 its synthesis route is as follows.
7-F4- (2-HVDROXVETHYLIDENE) PIPERIDIN-1-YLL-1-CVCLOPROPVL-6-FLUORO-4-OXO-1, 4- DIHVDRONAPHTHYRIDINE-3-CARBOXVIIC acid (163) A solution of amine 103 (256 mg, 1.06 MMOL) and triethylamine (0.5 mL, 3.55 MMOL) in ACETONITRILE (4 mL) was treated with 7-CHLORO-1-CYCLOPROPYL-6-FLUORO-4-OXO-1, 4-dihydro-naphthyridine-3- carboxylic acid (200 mg, 0.71 MMOL) under nitrogen and the reaction mixture was allowed to stir for 16 h. The resulting mixture was concentrated in vacuo, and the residue was washed with water (3 x 10 mL) and allowed to dry overnight to afford the title compound 163 (105 mg, 40%). MS 374 (M+H).
100361-18-0, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,100361-18-0 ,7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid, other downstream synthetic routes, hurry up and to see
Reference£º
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2005/33108; (2005); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem