As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO345,mainly used in chemical industry, its synthesis route is as follows.,215523-34-5
To a suspension of 1,8-naphthyridine-2-carboxylic acid (2?g, 0.011?mol) in dry benzene (50?mL), was added oxalyl chloride (1.4?mL, 0.017?mol) drop wisely at 0?C. Then few drops of DMF were added and the reaction began immediately. It was then slowly brought to room temperature and heated at 65?C for 3?h until the gas evolution subsided. The solvent and excess oxalyl chloride was removed under reduced pressure to afford a light yellow residue of 1,8-naphthyridine-2-carbonyl chloride in almost quantitative yield which was directly used for the next step without further purification.
With the synthetic route has been constantly updated, we look forward to future research findings about 1,8-Naphthyridine-2-carboxylic acid,belong naphthyridine compound
Reference£º
Article; Sarkar, Mithun; Pandey, Pragati; Bera, Jitendra K.; Inorganica Chimica Acta; vol. 486; (2019); p. 518 – 528;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem