As a common heterocyclic compound, it belongs to naphthyridine compound, name is 2-Chloro-1,8-naphthyridine, and cas is 15936-10-4, its synthesis route is as follows.,15936-10-4
Example 82; 5-Methvl-6- (1, 8-naphthyridin-2-yl)-N [4-trifluoromethvl phenvl] pyrimidin-4-amine; To a mixture of Description 95 (200 mg, 0.7 mmol), Description 92 (115 mg, 0.7 mmol) and Pd (PPh3) 4 (80 mg, 0.07 mmol) in anhydrous 1, 4-dioxane (4 ml) was added hexamethylditin (0. 145 ml, 0.7 mmol). The mixture was heated at 190C for 15 min in a microwave reactor (Personal Chemistry-Smith synthesizer). The cooled reaction mixture was loaded directly onto a silica gel chromatography column and eluted with 2% MeOH + 0. 5% NH40H in DCM. The product was further purified by mass directed HPLC to give the title compound as a white solid (50 mg, 18%). 1H NMR (500 MHz, CDCl3) 2.70 (3 H, s), 6.94 (1 H, s), 7. 58 (1 H, dd, J8.1 and 4.2), 7.64 (2 H, d, J8.6), 7.84 (2 H, d, J8.6), 8. 25 (1 H, d, J8. 5), 8.29 (1 H, dd, J8. 1 and 1. 9), 8.38 (1 H, d, J 8. 4), 8. 81 (1 H, s), 9.20 (1 H, dd, J4.2 and 1.9) ; mlz (ES+) 382 (M+H+).
With the complex challenges of chemical substances, we look forward to future research findings about 15936-10-4,belong naphthyridine compound
Reference£º
Patent; MERCK SHARP & DOHME LIMITED; WO2005/47279; (2005); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem