100491-29-0, Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate is a naphthyridine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,100491-29-0
Example 7 7-Chloro-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid. A mixture of tetrahydrofuran (450 cm3), water (50 cm3), methanesulfonic acid (127 cm3) and ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate (United Kingdom Patent Publication No. GB 2,191,776) was heated at reflux for 1 hour, and then cooled to 25C. The resulting crystals were isolated, washed with tetrahydrofuran, and dried under vacuum to afford 41.3g (89%) of the above-titled compound: m.p. = 250C; (Found: C, 50.4; H, 1.7; Cl, 9.9; F, 16.0; N, 8.0. C15H6CIF3N2O3requires C, 50.8; H, 1.7; Cl, 10.0; F, 16.1; N, 7.9%); 1H NMR (300 MHz, d6-DMSO) delta 13.9 (s, 1H), 9.09 (s, 1H), 8.77 (d, J= 7.5 Hz, 1H), 7.86 (td, J= 5.9 and 8.8 Hz, 1H), 7.66 (ddd, J= 2.7, 9.0 and 11.8 Hz, 1H), 7.39 (tm, J= 8.6 Hz, 1H), 7.39 (tm, J= 8.6 Hz, 1H); numax(DRIFTS) cm-13130, 3060, 2947, 2885, 2821, 2723, 2637, 2594, 1734, 1641, 1623, 1579, 1544,1516.
100491-29-0 Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 1268243, anaphthyridine compound, is more and more widely used in various fields.
Reference£º
Patent; Pfizer Products Inc.; EP976749; (2000); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem