54920-82-0, 1,7-Naphthyridin-2(1H)-one is a naphthyridine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
54920-82-0, Example 29 7-benzyl-5,6,7,8-tetrahydro-1,7-naphthyridine-2(1H)-one Ethanol (20 mL) and benzyl bromide (0.8 mL) were added to 1,7-naphthyridine-2(1H)-one (CAS registration No: 54920-82-0) (900 mg), and the mixture was heated and stirred at 80¡ãC for 18 hours. The mixture was cooled to 0¡ãC, and then sodium borohydride (1100 mg) was added to the mixture. The mixture was stirred at 0¡ãC for 10 minutes, then hydrochloric acid was added thereto, and the mixture was stirred for 90 minutes at room temperature, followed by neutralization with sodium hydroxide. Then, ethyl acetate was added to the mixture, and the organic layer was extracted. The organic layer was washed with a saturated saline solution, dried over anhydrous sodium sulfate, and a solvent was removed by evaporation under reduced pressure. Thereafter, the resulting solid was washed with ethyl acetate to obtain the title compound (900 mg) having the following physical property values. 1H-NMR (CD3OD): delta 2.66, 2.80, 3.45, 3.75, 6.40, 7.29-7.44.
The synthetic route of 54920-82-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Ono Pharmaceutical Co., Ltd.; INUKAI, Takayuki; TAKEUCHI, Jun; YASUHIRO, Tomoko; (50 pag.)EP3239147; (2017); A1;,
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