With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35192-05-3,2-Chloro-1,7-naphthyridine,as a common compound, the synthetic route is as follows.
2-Chlorb-[l,7]naphthyridine (100 mg, 0.61 mmol) , 2-amino-N- (4- tert-butyl-phenyl) -benzamide (164 mg, 0.61 mmol),Pd2(dba)3 (6 mg, 0.006 mmol), (2 ‘ -Dicyclohexylphosphanyl-biphenyl – 2 -yl) -dimethyl -amine (6 mg, 0.015 mmol), and 1Msolution of LiN(TMS)2 in THF (1.83 inL) , 1.83 mmol) wereadded to a reaction vessel. The vessel was sealed and thereaction was stirred at 70 aC for 24h. The mixture wascooled to RT, and solvent was removed under vacuum. Thecrude was purified by flash column chromatography (gradiant,0 to 100% EtoAC/Hexane) to give the product as tan solid. MS(ES~) : 397.0 (M+H) + . Calc’d for C25H24N40 – 396.20., 35192-05-3
35192-05-3 2-Chloro-1,7-naphthyridine 20696625, anaphthyridine compound, is more and more widely used in various fields.
Reference£º
Patent; AMGEN INC.; WO2006/12374; (2006); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem