952059-69-7, 8-Chloro-3-methoxy-1,5-naphthyridine is a naphthyridine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,952059-69-7
Example 14; N-(l-ethyl-lJHr-pyrazol-4-yl)-2-[2-methoxy-4-(7-methoxy-l,5-naphthyridin- 4-yloxy)phenyl] acetamide; Under an atmosphere of argon, a mixture of 4-chloro-7-methoxy-l,5-naphthyridine (0.09 g), N-(l-ethyl-lH-pyrazol-4-yl)-2-(4-hydroxy-2-methoxyphenyl)acetamide (0.127 g), caesium carbonate (0.453 g) and DMF (1 ml) was stirred and heated to 900C for 7 hours. The mixture was cooled to ambient temperature and poured into water. The resultant mixture was filtered. The solid so obtained was purified by column chromatography on silica using increasingly polar mixtures of methylene chloride and methanol as eluent. There was thus obtained the title compound as a solid (0.12 g); 1H nuMR Spectrum: (DMSOd6) 1.32 (t, 3H)3 3.59 (s, 2H), 3.76 (s, 3H)5 4.0 (s, 3H), 4.07 (q, 2H)5 6.76 (d, IH), 6.77 (m, IH)5 6.94 (d, IH)5 7.31 (d, IH), 7.42 (s, IH), 7.79 (d, IH), 7.87 (s, IH)5 8.71 (d, IH)5 8.73 (d, IH)5 10.04 (s, IH); Mass Spectrum: M+?t 434.
As the paragraph descriping shows that 952059-69-7 is playing an increasingly important role.
Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/113548; (2007); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem