100491-29-0, Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate is a naphthyridine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A. Ethyl 7-([S,S]-2,8-diazabicyclo[4.3.0]non-8-yl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate 1.9 g (5 mmol) of ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate are stirred with 680 mg (5.4 mmol) of [S,S]-2,8-diazabicyclo[4.3.0]nonane at 10 C. for 3 hours in 20 ml of acetonitrile and in the presence of 560 mg (5 mmol) of 1,4-diazabicyclo[2.2.2]octane. The suspension is filtered with suction, washed with water and dried. 0.35 g of product is obtained. By concentrating the mother liquors, stirring the residue with water, isolating the undissolved product and purifying by chromatography (silica gel, eluent: dichloromethane/methanol/17% strength aqueous ammonia), a further 0.7 g of product is isolated. Total yield: 1.05 g (44% of theory), Melting point: 184-185 C. (with decomposition), [alpha]D23: +6.8 (c=0.46, CHCl3)
100491-29-0, As the paragraph descriping shows that 100491-29-0 is playing an increasingly important role.
Reference£º
Patent; Bayer Aktiengesellschaft; US5480879; (1996); A;,
1,8-Naphthyridine – Wikipedia
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