As a common heterocyclic compound, it belong naphthyridine compound,8-Chloro-2-methoxy-1,5-naphthyridine,249889-68-7,Molecular formula: C9H7ClN2O,mainly used in chemical industry, its synthesis route is as follows.,249889-68-7
81.i. N1-(6-methoxy-[1,5]naphthyridin-4-yl)-ethane-1,2-diamine A mixture of 8-chloro-2-methoxy-1,5-naphthyridine (1.71 g, 8.81 mmol) and ethylenediamine (1.18 mL, 2 eq.) was heated slowly to 80 C. over 1 h and subsequently up to 100 C. for 2 h. After cooling to rt, the yellow solution was taken in DCM and successively washed with NaHCO3. The aq. layer was back extracted with DCM (3 times) and the combined org. layers were concentrated to afford the title intermediate as a pale yellow oil (0.98 g, 51% yield). MS (ESI, m/z): 219.4 [M+H+].
With the synthetic route has been constantly updated, we look forward to future research findings about 8-Chloro-2-methoxy-1,5-naphthyridine,belong naphthyridine compound
Reference£º
Patent; Actelion Pharmaceuticals Ltd.; US2010/137290; (2010); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem