249889-68-7, 8-Chloro-2-methoxy-1,5-naphthyridine is a naphthyridine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
81.i. N1-(6-methoxy-[1,5]naphthyridin-4-yl)-ethane-1,2-diamine A mixture of 8-chloro-2-methoxy-1,5-naphthyridine (1.71 g, 8.81 mmol) and ethylenediamine (1.18 mL, 2 eq.) was heated slowly to 80 C. over 1 h and subsequently up to 100 C. for 2 h. After cooling to rt, the yellow solution was taken in DCM and successively washed with NaHCO3. The aq. layer was back extracted with DCM (3 times) and the combined org. layers were concentrated to afford the title intermediate as a pale yellow oil (0.98 g, 51% yield). MS (ESI, m/z): 219.4 [M+H+].
The synthetic route of 249889-68-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Actelion Pharmaceuticals Ltd.; US2010/137290; (2010); A1;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem