952059-69-7 8-Chloro-3-methoxy-1,5-naphthyridine 59427340, anaphthyridine compound, is more and more widely used in various.
With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.952059-69-7,8-Chloro-3-methoxy-1,5-naphthyridine,as a common compound, the synthetic route is as follows.
Example 38 (Method C2); Synthesis of 4-(4-tert-butylphenyl)-N-(4-(7-methoxy-l,5-naphthyridin-4- yloxy)phenyl)phthalazin-l-amineIn a nitrogen purged sealed tube, 8-chloro-3-methoxy-l,5-naphthyridine (0.053 g, 0.271 mmol) was dissolved in DMF (2.00 mL). 4-(4-(4-Tert-butylphenyl)phthalazin-l- ylamino)phenol (0.100 g, 0.271 mmol) and cesium carbonate (0.176 g, 0.541 mol) were added, and the mixture in the tube was stirred at 90 C for 17 h. Upon cooling to RT, the mixture was concentrated in vacuo, and purified by silica gel chromatography using 0- 100% CH2Cl2:MeOH(90: 1O)/CH2C12 to yield 4-(4-tert-butylphenyl)-N-(4-(7-methoxy- l,5-naphthyridin-4-yloxy)phenyl)phthalazin-l -amine as off-white solid. MS [M+H]=528.1; Calc’d 527.6 for C33H29N5O2.
952059-69-7 8-Chloro-3-methoxy-1,5-naphthyridine 59427340, anaphthyridine compound, is more and more widely used in various.
Reference£º
Patent; AMGEN INC.; WO2008/124083; (2008); A2;,
1,8-Naphthyridine – Wikipedia
1,8-Naphthyridine | C8H6N2 – PubChem